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Immune factors in human milk
In human milk, there is a complex system of antimicrobial factors... most of the factors are produced throughout lactation... Antibodies are present in human milk throughout lactation...
source:
According to the Iowa Extension Service, every teaspoon of breastmilk has 3,000,000 germ killing cells in it; so if a baby gets even one tsp. a day, it is very valuable!
.. it has been shown in man and in several animal models that immunisation via the gut, and also the lungs, stimulates a special population of antibody-producing B lymphocytes. They appear in large numbers in special aggregations in the gut - the Peyer's patches. These lymphocytes leave the gut after having met bacteria and viruses there and move or "home" to exocrine glands such as the mammary, lacrimal and salivary glands, as well as glands in the mucosal membranes of the bronchi and the gut. As a consequence, human milk contains sIgA antibodies against all those bacteria and viruses which have been in the mother's gut. This gives the milk capacity to protect against those microorganisms to which the infant is exposed, because they are usually the same as those its mother has been in contact with.source: L A Hanson et al. Breastfeeding protects against infections and allergy. Breastfeeding Review; Nov l988 , pp l9 - 22.
Some of the immune factors in breastmilk have been shown to increase in concentration as the baby gets older and nurses less, so older babies still receive lots of immune factors. So as a baby starts to nurse less (weaning) and milk supply decreases, the concentration of immunities increases. This isn't age-dependent, but depends on the amount of milk that baby is removing from the breast. [source: Goldman AS et al. "Immunologic components in human milk during weaning." Acta Paediatr Scand. 1983 Jan;72(1):133-4.]
Sources:
Table 6-5 "Concentration of Immunologic Factors in Human Milk During Several Phases of Lactation" from:
Table 5-2 "Concentration of immunologic components in human milk collected during second year of lactation" from: Lawrence R and Lawrence R. Breastfeeding: A Guide for the Medical Profession, 5th ed. St. Louis: Mosby, 1999, p. 169 .
Immune factors found in human milk
alpha-Lactalbumin (variant)
alpha-lactoglobulin
alpha2-macroglobulin (like)
ß-defensin-1
Bifidobacterium bifidum
Carbohydrate
Casein
CCL28 (CC-chemokine)
Chondroitin sulphate (-like)
Complement C1-C9
Folate
Free secretory component
Fucosylated oligosaccharides
Gangliosides GM1-3, GD1a, GT1b, GQ1b
Glycolipid Gb3, Gb
Glycopeptides
Glycoproteins (mannosylated)
Glycoproteins (receptor-like)
Glycoproteins (sialic acid-containing or terminal galactose)
Haemagglutinin inhibitors
Heparin
IgG
IgM
IgD
kappa-Casein
Lactadherin (mucin-associated glycoprotein)
lactoferrin
Lactoperoxidase
Lipids
Lysozyme
Milk cells (macrophages, neutrophils, B & T lymphocytes)
Mucin (muc-1; milk fat globulin membrane)
Nonimmunoglobulin macromolecules (milk fat, proteins)
Oligosaccharides
Phosphatidylethanolamine
(Tri to penta) phosphorylated beta-casein
Prostaglandins E1, E2, F2 alpha
RANTES (CC-chemokine)
Ribonuclease
Secretory IgA
Secretory leukocyte protease inhibitor (antileukocyte protease; SLPI)
Sialic acid-glycoproteins
sialylated oligosaccharides
Sialyllactose
Sialyloligosaccharides on sIgA(Fc)
Soluble bacterial pattern recognition receptor CD14
Soluble intracellular adhesion molecule 1 (ICAM-1)
Soluble vascular cell adhesion molecule 1 (VCAM-1)
Sulphatide (sulphogalactosylceramide)
Trypsin inhibitor
Vitamin A
vitamin B12
Xanthine oxidase (with added hypoxanthine)
Zinc
Unidentified factorsSource:
Human milk - Tables of the antimicrobial factors and microbiological contaminants relevant to human milk banking (with continued updating)
Additional Information
Field CJ.
Immune Benefits of Breast Milk at a Glance by Robert J. Huskey
Goldman AS, Chheda S, and Garofalo R.
Dai D, Walker WA.
Goldman AS.
Importance of Glycoconjugates in Breastfeeding and Early Nutrition by Tom Gardiner, PhD, from Glycoscience and Nutrition 2000 July;1(23):1-10.
Kirsi-Marjut Järvinen.
How the Immune System Develops
Page last modified: 08/22/2005
Written: 06/01/2001